When developing an industrial fermentation process, the choice of the production organism dictates much of the large-scale fermentation characteristics in addition to the nature of research and development and process development. Well characterized strains with a large genetic manipulation tool set, such as Escherichia coli, can rapidly deliver R&D goals, yet E. coli tends to be a challenging strain for the development of a robust, reproducible fermentation process at large scale. Other microbial hosts, such as yeast (e.g. Saccharomyces cerevisiae), have earned the reputation of being robust and reliable producers at large scale although the R&D pathway to a production strain may be more challenging than E. coli.
When selecting a production host for a new fermentation process, one needs to keep the end in mind. If the goal is to develop a fermentation process that is easily scalable, robust, and one that readily withstands environmental variations as seen in large production fermenters, choosing the host strain wisely will be a major factor with long-term consequences. The goal is obviously to choose the host that consistently delivers production and economic metrics. To do this, it is important to have the input of experts with an in-depth knowledge of microbial production stains, and especially those with experience with how they will perform at large scale.
Large renewable energy and biochemical consulting firms like Lee Enterprises Consulting will certainly have experts in industrial fermentation. They also offer a wide range of services in the general areas of biofuels, biochemicals, biotechnologies, biomaterials, synthetic biology commercialization, feedstocks, and hemp/cannabis, and will have many specialized business and financial services like due diligence, feedstock availability, grants and loans and bio market research. A big consulting group like this should also offer technical and engineering related services like techno economic analysis, environmental evaluations, feasibility studies, risk analysis and expert witness engagements, and have solid strategic partnerships in place to assist clients with insurance, legal, accounting, plant fabrication, feedstock procurement.
With over 150 experts worldwide, Lee Enterprises Consulting has experts in many specific clean and renewable areas, including anaerobic digestion, fermentation, biomass, conversion technologies for things like tires and railroad ties, organic synthesis, fuel additives, ethanol gas, biodiesel fuel including algae biofuels, solid state and industrial fermentation, green energy grants, ag biotech, agricultural waste, alcohol fuels, alternative proteins and animal-free products, sustainable foods, beverage fermentation, biocatalysis, biodiesel conversion, biogas production, biomass power, carbon intensity, co2 utilization, combined heat & power, Fischer-Tropsch technology, food waste, hydrothermal carbonization, industrial enzymes, landfill management, microbial fermentation, organic synthesis, plastic pyrolysis, plastic recycling, plastic waste, pyrolysis oil, reactor design, renewable identification number, the Renewable Fuel Standard (rfs2), solid recovered fuels, torrefaction and torrefied biomass, waste to energy, and waste-to-hydrogen. This is a multidisciplinary group of green energy consultants that is a virtual “one stop shop” for any client need and handles projects of all types and sizes.
Look at our experts and the services we provide. Most of our experts are also available to advise and serve as expert witnesses in bioeconomy litigation matters. For the larger projects, we specialize in putting together full service, interdisciplinary teams with one point of contact. See video about LEC here. Call us at 1+ (501) 833-8511 or email us for more information. See also: Industrial Fermentation Expert.