Industrial Fermentation: Selecting the Host Strain

When developing an industrial fermentation process, the choice of the production organism dictates much of the large-scale fermentation characteristics in addition to the nature of research and development and process development.  Well characterized strains with a large genetic manipulation tool set, such as Escherichia coli, can rapidly deliver R&D goals, yet E. coli tends to…

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Advanced Fermentation Agitation with Methanotrophs and Other Organisms

By Gregory T. Benz, Lee Enterprises Consulting Introduction Advanced fermentation processes, both aerobic and anaerobic, have been successful on an industrial scale for quite a long time, producing a wide variety of products. In most of these processes, if any gas has been added, it has been either air or oxygen-enriched air. In the advanced bioeconomy,…

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Optimum Aspect Ratio for a Fermenter

What is the optimum aspect ratio (or height/diameter ratio) is for a fermenter?   The best answer is “it depends”. There is simply no universal optimum. The best design is worked on a case-by-case basis. We can list some factors that affect the optimum. Note that as aspect ratio increases, the following results are produced: The…

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Heat Transfer Issues in Mechanically Agitated Fermenters

Heat Transfer Issues in Mechanically Agitated Fermenters? Aerobic fermentation generates a significant amount of heat, which must be removed to maintain a constant temperature. The main heat sources are metabolic heat generation, agitator power input, and compressor power input. Removing the heat is made more challenging by the fact that fermenters are operated at mild…

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Fermentation Expert

A fermentation expert refers to one who assists with the aerobic or anaerobic growth of bacteria, fungi, algae, and yeasts, or fungi in glass or steel vessels outfitted with temperature and other environmental controls. Solid-state fermentation is often completed in trays of media; and is a fermentation process occurring in the near absence of free liquid,…

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Industrial Biotech Scale Up

Industrial biotech uses fermentation processes to make biofuels, biobased chemicals, specialty chemicals, nutraceuticals (e.g. cannabidiol), and even ingredients for the recent rise of meat, dairy, and seafood substitutes.  Once a company has a bioprocess (including fermentation and purification) fully tested and optimized at lab scale, then the company needs to prepare itself before industrial biotech…

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